•CellREDM and Re2O are distinct hADM products based on extracellular matrix (ECM) derived from human dermis.
•A trial of Re2O combined with HA observed improvements in skin density, elasticity, wrinkles, pores, hydration and barrier measures; it did not directly compare CellREDM with Re2O.
•Product selection considers skin thickness, the treatment area, individual concerns and previous treatments.
Skin aging treatmentSkin Booster Notes
CellREDM vs Re2O: What is the difference?hADM skin boosters and a new approach to skin aging
Creating the environment in which skin cells live. INEE Clinic explains hADM skin boosters: an approach that considers the entire extracellular matrix surrounding skin cells, rather than collagen alone.
SKIN & MATRIXECM within the skin layers
CollagenSupports structure and strength
ElastinContributes to elasticity and recoil
GAGs · HydrationSkin components that support tissue structure and hydration
FibroblastsCells that produce collagen, elastin and other elements important for skin elasticity
If skin cells are the residents, the extracellular matrix (ECM) is their home. The droplets symbolize the hydration environment, not the shape of GAG molecules. Layer thicknesses and component sizes are simplified for clarity.
Sometimes skin feels thinner, fine lines become more noticeable and texture grows rougher, yet a lack of moisture alone does not seem to explain these changes. In fact, no single component fully accounts for them.
With age, collagen decreases, elastin structure changes and other extracellular matrix components supporting skin cells also change. This is why the ECM, or extracellular matrix, has attracted attention in treatments for skin aging.
The key point
CellREDM and Elravie Re2O, used at INEE Clinic, are both hADM-based treatments focused on the ECM. They address the environment surrounding skin cells as well as collagen itself.
The two products belong to the same material category, but they are not identical. The choice depends less on the product name than on what has changed most in your skin.
What is hADM?
hADM stands for human acellular dermal matrix. It is a material processed from human dermis to remove cellular components while retaining the extracellular matrix, or ECM, that formed the skin's supporting structure.
If cells are the residents of our skin, the ECM is like the home surrounding them. Major skin ECM components include the following.
Collagen
Supports the structure and strength of skin.
Elastin
Contributes to skin elasticity and recoil.
GAGsGlycosaminoglycans
Contribute to moisture retention and the ECM environment.
ADM is not simply a collagen supplement. It is a biomaterial processed to preserve the inherent structural and biological characteristics of the extracellular matrix (ECM).[2,3]
Why consider the whole ECM, rather than collagen alone?
Think of skin as a building. Collagen is like its pillars and framework. But pillars alone do not make a sound building. Connections between the pillars, elastic elements and an environment that retains moisture all contribute to stable tissue. Skin works in a similar way.
Aging skin undergoes not only a decrease in collagen, but also changes in elastic fibers and the structure of the ECM.
01Dermis in younger skin
Collagen, elastin and the hydration environment work together to support skin cells.
02Dermis in aging skin
Collagen quantity and arrangement, elastic fibers and the ECM environment change together.
A simplified conceptual illustration of age-related changes.
Beyond “not enough collagen”: “The entire extracellular matrix around skin cells is changing.”
Understanding skin aging from this perspective is becoming increasingly important.[2,3]This is also one of the most interesting aspects of hADM treatment.
What skin changes might hADM help address?
Studies have begun to evaluate what happens when hADM is injected into the skin. The following five endpoints were examined in a clinical study published in 2026.[1]
FIVE RESEARCH ENDPOINTSFive endpoints, from skin structure to the surface
EpidermisDermis · ECMSubcutis
Numbers connect the illustration to the endpoints. They do not indicate that each endpoint involves only one layer.
These changes were observed in this particular study. They do not establish a direct comparison between the two products or mean that every patient will experience the same results.
Select a skin concern to learn more
Tap an item below to open the detailed explanation and research findings.
01Skin densityDermal structure and supportRead moreClose
Skin that feels a little firmer
As collagen quantity and arrangement in the dermis change with age, skin may feel thinner and less firm. In the clinical study, skin density increased on the side treated with phADM in addition to HA, with greater improvements than the HA-only side at several time points.[1]
In the animal tissue experiments included in the same study, fibroblasts were observed migrating around phADM, together with new collagen formation, or neocollagenesis.[1]Researchers are investigating whether hADM can act as an ECM scaffold that interacts with surrounding tissue, rather than simply occupying space.
Skin density
02Skin elasticityThe skin's ability to spring backRead moreClose
Improved skin elasticity
Elastin, as well as collagen, plays an important role in skin elasticity. If collagen provides the supporting framework, elastin is the elastic structure that helps skin return to its original shape after movement.
Depending on the product and manufacturing process, hADM may retain ECM components such as elastin and GAGs in addition to collagen.[2,3]The clinical trial also observed improvements in skin elasticity measures on the side treated with phADM in addition to HA.[1]If your skin feels thinner and less resilient rather than simply dry, an approach that considers both elasticity and dermal structure may be relevant.
Elasticity
03Fine lines · TextureThe skin surface and dermal environmentRead moreClose
Improved fine lines and skin texture
Fine lines are more than lines on the skin's surface. Photoaging and age-related changes in the dermal ECM also contribute. The study observed improvements in wrinkle depth and skin surface measures on the side treated with phADM in addition to HA.[1]
hADM is not a treatment that immediately lifts deep wrinkles in the same way as a filler. Its approach to fine lines focuses on skin quality and the dermal environment.
Wrinkle depth
04PoresSupport around the poresRead moreClose
Pores that appear less noticeable
There are several reasons why pores can appear enlarged. Sebum production matters, but weakening of the elasticity and dermal structure around pores with age can also contribute. Not all enlarged pores should therefore be treated in the same way.
The trial observed a decrease in pore area on the side treated with phADM in addition to HA.[1]If pores have gradually become more noticeable alongside reduced skin elasticity, hADM may be considered from this perspective.
Pore area
05Hydration · BarrierAn environment that retains moistureRead moreClose
Improved hydration and barrier-related measures
Hydration depends on more than the amount of water in the skin. An environment that retains water and a functioning skin barrier are also important. GAGs are among the key ECM components that interact with water.
The trial observed increased skin hydration and reduced TEWL, or transepidermal water loss, on the side treated with phADM in addition to HA.[1]Cell experiments also identified changes related to hyaluronan production in keratinocytes.[1]The relevance of hADM lies in considering the environment that helps skin retain moisture, rather than simply adding water to the skin.
Hydration · TEWL
INEE Clinic uses CellREDM and Re2O
Both products use acellular dermal matrix derived from human dermis, but they are not the same product.
CellREDMCellREDM
A human-derived ECM skin booster from HansBiomed.
Described in official product materials as micronized acellular dermal matrix[5]
Listed as containing collagen, elastin and GAGs[5]
Characterized by its inclusion of several ECM components found in skin
By incorporating multiple components of the extracellular matrix rather than a single ingredient, the product reflects the hADM approach of supporting the skin's environment.
Re2OElravie Re2O
A particulate hADM product developed by L&C Bio.[4]
The product used in the clinical study published in 2026[1]
A study comparing Re2O mixed with HA against HA alone[1]
Improvements observed in density, elasticity, wrinkles, pores, hydration and barrier measures[1]
Among these two products, Re2O is distinguished by the direct, peer-reviewed clinical evidence for injectable hADM skin treatment cited here.
Which is better: CellREDM or Re2O?
There is no simple answer in the form of a product name. Although both are based on hADM, their physical and processing characteristics differ, and each person's skin is different.
Thin skin around the eyes cannot be treated in exactly the same way as the relatively thicker skin of the cheeks. For some people, fine lines are the main concern; for others, it is pores and texture, or thinning skin and reduced elasticity.
Rather than using one product in the same way for every patient, INEE Clinic considers the following factors before choosing the product and treatment approach.
Skin thickness
Pattern of aging
Treatment area
Skin texture
Degree of elasticity loss
Previous treatments
Is hADM the same as a filler?
No. Fillers primarily address volume and shape, whereas hADM focuses on the structure and quality of the skin itself.
When a filler may be more suitable
One of the main purposes of conventional HA fillers is to add physical volume to hollow areas and adjust facial contours.
When pronounced cheek hollowing requires substantial volume restoration
When a sunken area needs physical volume replacement
When immediate elevation of a deep wrinkle is the goal
In these situations, a filler or another volumizing treatment may be more appropriate.
When hADM may be considered
hADM treatment is oriented more toward skin structure and quality than toward volume.
“My skin feels thinner and less firm.”
“Fine lines and visible pores have both increased.”
“My skin feels rougher and less elastic than before.”
If these are your concerns, hADM may be considered as one option for skin treatment.
hADM treatment involves more than a product name
Discussions about skin boosters often focus on which product was used. In practice, the following factors also matter.
Where, at what depth, how much, and at what intervals?
Even within the same face, the eye area, cheeks, mouth area and neck differ in skin thickness and anatomy. In some cases, treatment may be combined with lasers, energy-based devices, PN, collagen or HA treatments.
The starting point for appropriate treatment is therefore an accurate assessment of what has changed most in the skin, rather than choosing a particular product first.
References
Lee YI, Chau NH, Nguyen NH, et al. Injectable Particulated Human Acellular Dermal Matrix Booster for Skin Restoration: An Integrated Randomized, Split-Face, Double-Blinded Clinical Trial and Preclinical Study. Int J Mol Sci. 2026;27(5):2193. doi:10.3390/ijms27052193
Sydorchuk O, Nguyen AT, Yi KH. Acellular Dermal Matrices in Aesthetic Surgery: Clinical Applications. J Cosmet Dermatol. 2026;25(7):e71043. doi:10.1111/jocd.71043.
L&C Bio. Elravie Re2O official product information. Human acellular dermal matrix-based product information.
HansBiomed Corp. CellREDM™ official product information. Human-derived ECM skin booster composed of acellular dermal matrix containing collagen, elastin and GAGs.
Note: References 1–3 are academic publications. References 4–5 are official manufacturer materials used to check raw materials and composition; they are not cited as clinical evidence of the same level as peer-reviewed studies.
ByDr. Min-seong Kim · INEE Clinic
Published September 4, 2026
FAQ
QWhat does it mean that hADM is made from human skin?
AhADM is a biomaterial processed from donated human dermal tissue to remove cellular components while retaining the extracellular matrix (ECM). ADM has been used in several medical fields, including skin and soft-tissue reconstruction. More recently, researchers have explored processing it into fine particles for aesthetic skin treatments. Raw-material processing and manufacturing differ between products, so the characteristics of the specific product should be checked.
QHow does it differ from Rejuran or collagen skin boosters?
AThe materials are different. PN products such as Rejuran are based on polynucleotides, while purified collagen products supply a particular type of collagen. hADM, by contrast, is based on extracellular matrix derived from the dermis. These treatments therefore do not have identical roles. Selection, and whether to combine treatments, depends on the skin condition, treatment goals and the characteristics of each product.
QWhat benefits might hADM treatment offer?
AA Re2O study published in 2026 compared phADM (Re2O) plus HA with HA alone and observed improvements in skin density, elasticity, wrinkle depth, pore area, hydration and barrier-related measures. The approach is therefore better understood in terms of skin firmness, smoothness, fine lines, texture and hydration than major volume changes. These findings apply to the study conditions and do not guarantee the same results for every hADM product or patient.
QHow should I choose between CellREDM and Re2O?
ABoth are hADM-based, but they are different products. Official materials describe CellREDM as micronized hADM containing collagen, elastin and GAGs. Re2O was the phADM product used in a randomized split-face clinical trial published in 2026. That trial did not directly compare these two products and cannot establish that one is superior to the other. At INEE Clinic, product and treatment selection follows an assessment of skin thickness, the treatment area and the desired changes.
QCan I judge the results immediately after treatment?
AhADM should not be viewed as equivalent to a filler intended to create immediate volume. The Re2O trial assessed changes over 20 weeks after treatment, observing changes in measures including skin density, elasticity and hydration over time. Assessment should therefore include follow-up rather than the immediate appearance alone. Twenty weeks was the study’s observation period, not a promised onset or duration of effect for every patient.
